Welcome to Week 1

Welcome to the first Week of this course.

We start by investigating the difference between reference and draft genomes, and we will learn how genomes can be assembled from smaller fragments of DNA sequence.

We will also learn about genome browsers and why we need them. We focus on a purpose-designed genome browser called Artemis, which was developed by scientists and researchers here at the Wellcome Sanger Institute.

We will be considering the importance of genome browsers and how Artemis has contributed to the study of bacterial pathogens through an interview with Professor Julian Parkhill, who shares his knowledge, experience and insights. In his current work, Julian, Senior Group Leader, Pathogen Genomics, uses high-throughput sequencing and phenotyping to study pathogen diversity and variation, how they affect virulence and transmission, and what they tell us about the evolution of pathogenicity and host interactions.

In another Interview, we consider the use of genome browsers from the perspective of Matthew Dorman, one of the Lead Educators for this course, and a graduate student at the Wellcome Sanger Institute, where he researches the virulence and the molecular genetics of bacterial pathogens. Matthew uses genome browsers in his day-to-day research investigating bacterial genomes.

We hope you are as excited as we are about this week’s activities. Remember to participate in the discussions by writing and sharing your comments, questions and suggestions in the comments area in each Step.

We are looking forward to reading and responding to your comments in the comments area.

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This article is from the free online course:

Bacterial Genomes: Accessing and Analysing Microbial Genome Data

Wellcome Genome Campus Advanced Courses and Scientific Conferences