Example: how to avoid overestimating and underestimating a patient’s renal function
After a brain exercise for the timing to adjust the dose, Prof. Brown gives an example for Januvia (Sitagliptin) adjustment.
When the value of CLcr using ideal body weight (IBW) is an underestimate, and the value of CLcr using actual body weight is an underestimate, what will you do?
Do you want to be more aggressive, or more conservative on the drug use? It is not easy to make the decision, however, you can find some clues in this video.
Finally, he clarifies the differences between hepatic and renal drug elimination. What are the differences between estimating liver and kidney function? Please leave your answer below and explain why.
Educator:
Prof. Daniel L. Brown
Clinical Pharmacokinetics: Dosing and Monitoring
Clinical Pharmacokinetics: Dosing and Monitoring
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