Hepatic Metabolism Review : How will Css change if fu changes?
Although we have learned the effect of fu increase before, this time we focus on how it impacts hepatic metabolism for a high E drug and a low E drug.
The hepatic metabolism review helps us consolidate knowledge. If you aren’t familiar with the concept, please review the previous video 4.7.
Besides, Prof. Brown gives a closer look at intrinsic clearance (CLint). Metabolic capacity depends on Vm and Km.
How will they affect CLint? Please leave your answer below and explain why.
Educator:
Prof. Daniel L. Brown
Clinical Pharmacokinetics: Dosing and Monitoring
Clinical Pharmacokinetics: Dosing and Monitoring
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