Skip to 0 minutes and 6 secondsFamilial Alzheimer's disease usually refers to those cases where it runs in the family but with a very high probability of developing the disease. So with what's called autosomal dominant familial Alzheimer's disease, you get one gene from each parent, and you only need one faulty gene to develop the disease. If you have a parent with familial Alzheimer's disease, you have a 50/50 chance of inheriting that gene, and if you inherit that faulty gene then it is very likely that you will develop the disease.
What is fAD?
Prof Martin Rossor gives a brief introduction to familial Alzheimer’s disease and how it is inherited in families.
Familial Alzheimer’s disease is very rare, it is thought to account for less than 1% of people with Alzheimer’s disease. Because dementia is very common, lots of people may have a number of family members with dementia, but that doesn’t mean they have this inherited, familial form. It’s when there are a many people in a family who develop Alzheimer’s disease quite young (before 65) that a doctor may consider suggesting a test for the familial Alzheimer’s disease genes. We’ll take a more detailed look at how familial AD is diagnosed, and the different genes involved in familial and non-familial Alzheimer’s disease in Steps 1.8 and 1.10.
Your questions and answers
At the end of this week we’ll be putting some of your questions about this topic to the experts who were interviewed. If you have a question you’d like us to answer, please post it as a comment in the Your questions and answers step (the last step of the week). You can also ‘like’ other people’s questions, and at the end of the week we’ll try to answer some of the most ‘liked’ questions, and post the answers on the Your questions and answers page.
© UCL 2016 - CC BY 4.0