Skip to 0 minutes and 10 secondsGram-negative bacteria are a group of organisms that can be found in water, soil, plants, but also in our intestinal flora, well-known as the microbiome. These bacteria may cause infections that can range from an uncomplicated urinary tract infection to more severe, life-threatening infections, for which we have no antibiotics to cure in some cases. In this course, you will learn microbiology, epidemiology, clinical presentation, and antibiotic choices to treat infections caused by gram-negative organisms, ranging from an uncomplicated urinary tract infection caused by E. coli to more serious infections caused by other organisms like pseudomonas. These infections have been a threat to public health worldwide. Some gram-negative infections may cause food-borne illnesses, may cause serious health care-associated infections like pneumonia and sepsis.

Skip to 1 minute and 19 secondsThe most important problem with gram-negative organisms is the continuous development of resistance. Some of these bacteria have become very smart, acquiring enzymes that destroy our first-line antibiotics, such as fluoroquinolones and beta-lactams. And in the worst cases, have developed enzymes called extended-spectrum beta-lactamases and carbapenemases that destroy our more potent beta-lactam antibiotic, and also our carbapenems. In this interactive modular e-learning course, you will learn about the microbiology, epidemiology, clinical presentation, and public health issues that are caused by gram-negative bacteria. You will learn about the best available evidence published to treat these infections, and how to prevent these bacteria to becoming more resistant to the current antibiotic armamentarium.

Skip to 2 minutes and 17 secondsThe course is designed for health care professionals worldwide interested in learning how to diagnose, treat, and prevent infections caused by gram-negative organisms.

Welcome to the course

In this video Dr Lilian Abbo, lead educator, welcomes you to the course and explains the value of understanding the role of Gram negative bacteria (GNB) in the conservation of antibiotics to treat infections globally.

This course has been developed by the British Society for Antimicrobial Chemotherapy as part of a Global programme of short courses to support healthcare professionals, involved in the management of infections, understanding of key elements of Antimicrobial Stewardship. We would like to acknowledge the support of our sponsor.

By the end of this course you will:

Have a basic understanding of the microbiology of GNB, their occurrence in the community and healthcare setting. 

Understand the occurrence of resistance in these important organisms, their epidemiology and basic mechanisms of resistance and the public health implications of the spread of antimicrobial resistance in gram negatives.

Appreciate the common clinical infections associated with common GNB, the setting of these infections, their burden and impact on health and economic outcomes.

Be aware of the basic microbiology requirements to diagnose these infections and the new technologies-diagnostics that will enhance the timeliness and overall detection of these pathogens.

Recognise the key objectives and principles of treatment in basic intermediate and advance scenarios of Gram negative infections.  

Understand current treatment options and new therapies- strengths and weaknesses; resume of guidelines/treatment pathways in this area.

Have a basic understanding of how appropriate use of these agents can be promoted in the healthcare setting- concept of stewardship for GNB infections.

We hope you will find this a very useful and practical experience to improve your learning, avoid further development of antimicrobial resistance and improve patient outcomes when dealing with these infection but please note the following:

Individuals and pathologies vary greatly. None of the opinions discussed as part of this course are designed, nor intended to be an offer to treat, prescribe or give advice to specific individuals. The research, opinions and content presented throughout the course should in no circumstances be solely relied upon by any learner. If a learner is suffering from a particular health condition being discussed during the course, they should always seek medical advice from a qualified practitioner.

Membership to the British Society for Antimicrobial Chemotherapy (BSAC) is free and a great way to keep up-to-date with antimicrobial resistance and stewardship practices.

You can then see how much of the course you’ve completed on your progress page.

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You can now get extra benefits by upgrading this course, including:

Unlimited access to the course: Go at your own pace with unlimited access to the course for as long as it exists on FutureLearn.

A Certificate of Achievement: To help you demonstrate your learning we’ll send you a Certificate of Achievement when you become eligible.

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This video is from the free online course:

Challenges in Antibiotic Resistance: Gram Negative Bacteria


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