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Skip to 0 minutes and 6 secondsHello again. I'm Dr David Leake. Today, I'd like to talk about smoking. The first thing to say about smoking is that it's the single most preventable risk factor for coronary heart disease. You can't bring your plasma cholesterol down to zero. You can't reduce your blood pressure to zero. That's not a good idea. But you can stop smoking entirely. Smoking reduces your life expectancy on average by 10 years. That's worth thinking about for a while. If you smoke 25 cigarettes a day, that increases your risk of getting a heart attack by four times. Smoking is also a major risk factor for peripheral arterial disease, a disease of the arteries of the legs.

Skip to 1 minute and 0 secondsAnd even in this day and age, that can lead to the leg amputations. That's the bad news. The good news is if you stop smoking, your risk of getting a heart attack goes down. Now it's not only active smoking that's injurious. If you're a passive smoker - you are exposed to smoke from people who do smoke - your risk of getting coronary heart disease goes up by about a quarter.

Skip to 1 minute and 33 secondsWhat are the injurious compounds in cigarette smoke? Well, we're not quite sure, but they could be nicotine, carbon monoxide, free radicals. These are reactive chemicals in smoke. It could be the carcinogenic compounds. Or it could be thiocyanate. And it's probably a mixture of a number of them. What are the mechanisms by which smoking increases coronary heart disease? Well, there's a lot of them. Smoking increases blood pressure, which is a major risk factor in itself. It increases the tendency of platelets to aggregate and gives you an increased chance of getting a thrombus. It damages endothelial cells that line blood vessels. It decreases HDL, high-density lipoprotein, and high-density lipoprotein may be a protective factor. Smoking increases inflammation.

Skip to 2 minutes and 35 secondsAnd don't forget that atherosclerosis is an inflammatory disease. Smoking will constrict blood vessels and so if they're short of oxygen that would make it even worse.

Skip to 2 minutes and 50 secondsAnd also, smoke contains carbon monoxide. And that binds with haemoglobin more strongly than oxygen does so it displaces oxygen from haemoglobin. And so if, say, the heart muscle is short of oxygen, that's going to make things even worse. Also, it decreases the age of menopause in women by 2 to 3 years. Women get coronary heart disease a full decade later than men. After the menopause when they stop producing eggs, that protection goes down. So if you hit the menopause sooner, then the time that which you get protection will also come down.

Learning about modifiable risk factors: Smoking

Mortality rates for cardiovascular disease have dropped by around 45% in the last 10 years. The reduction in smoking over the last few decades is thought to account for 60% of this reduction in mortality.

In this video, Dr David Leake explains how and why smoking increases the risk of cardiovascular disease and the remarkable reductions that we are seeing as the number of smokers decreases.

You can download the Week 4 supplement, which contains additional images and descriptions to help you understand the topics covered in this video.

British Heart Foundation resources

Find out more in the following, optional, video Smoking and heart disease; one of a series, produced by the British Heart Foundation Risking it: Fighting against risk factors in coronary heart disease.

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This video is from the free online course:

Heart Health: A Beginner's Guide to Cardiovascular Disease

University of Reading

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