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Welcome to Week 2

Welcome to week 2 of this course on Intravenous (IV) to Oral [Antimicrobial] Switch Therapy (IVOST) and the monitoring of complex oral antimicrobial regimens within the context of an Outpatient Parenteral Antibiotic Therapy (OPAT) service.

This week we will consider some of the clinical aspects of outpatient-based complex oral antimicrobial monitoring, sometimes called COPAT (Complex [Outpatient] Oral and Parenteral Antimicrobial Therapy). We will focus on what COPAT is and the prescribing of the antibiotic Linezolid.

This an important emerging area of expanded practice for OPAT services within the UK, particularly in the context of recently published clinical trials such as POET (endocarditis) and OVIVA (bone and joint infections), which will likely increase the number of patients undergoing early IVOST for complex infections.

As before, I strongly encourage you to engage with your fellow learners during the week by using the comments facility in each step. I hope you enjoy the week.

If you have any feedback on the week, please let us know.

Gavin Barlow

Main learning outcomes for week 2:

  • Think about, define and understand what complex oral antibiotic therapy is.

  • Understand the principles of prescribing and monitoring Linezolid.

  • Understand the adverse effects and other problems associated with prescribing Linezolid and how to mitigate for these.

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This article is from the free online course:

Intravenous to Oral Switch: Within Outpatient Parenteral Antibiotic Therapy (IVOST)


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