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Skip to 0 minutes and 14 seconds Therapeutic classes of biologics: anticoagulant, coagulant, anti-sense, colony-stimulating factor, erythropoietin, human growth hormone, interferons, interleukins, reverse transcriptase inhibitors, tissue necrosis factors, and the tyrosine kinase inhibitors. And as you can tell, I lay out all those categories or classes in their alphabetical order because I could not find any other better way to arrange them. And I will go through hopefully each and every class one by one. In addition, there are biosimilar products, and these products include insulin, human growth factor, epoetin, colony-stimulating factors. These biosimiar products are already on the market. And these classes are yet to come on the market for the biosimilars. These are the approved recommended proteins in 2014.

Skip to 1 minute and 36 seconds I just want to point out a couple of them, one is Saxena. This is a nucleotide natural appetite suppressant. It is actually the same ingredient as Victoza, indicated for type 2 diabetes. But the side effect of Victoza is weight loss. Therefore the manufacturer double the dose and make it into a weight loss agent. What a genius idea and Saxenda could become biologics of the century. These are the approved monoclonal antibodies in 2014. And again I just want to point out a couple of them. Opdivo is indicated for non-cancer. And Stelara is an IL-2, IL-23 antagonist which is indicated for psoriasis. And these are the peptides approved in 2014.

Skip to 2 minutes and 50 seconds Aveed and the Vogelxo, these are the testosterone product, jails, as a matter of fact, which are produced perhaps for those who cannot put up with the side effect of the PDE5 inhibitors. And Linzess, it’s also a nucleotide that is indicated for irritable bowel syndrome IBS.

Biologics and Biosimilar Overview

Therapeutic classes of biologics and biosimilars are presented, along with a list of then new approval in 2014. In a strict sense, reverse transcriptase inhibitors and tyrosine kinase inhibitors are small molecules; they are listed as biologics in light of their biochemical attributes and that genetic screening is often required in the clinical application.

In alphabetical order, biologics are therapeutically classified as Anticoagulant/Coagulant, Antisense Products, Colony Stimulating Factors, Erythropoietin, Human Growth Hormone, Interferons, Interleukins, Reverse Transcriptase Inhibitors, Tissue Necrosis Factors, and Tyrosine Kinase Inhibitors. Biosimilar products largely overlay with the original biologics, however with smaller numbers. A list of then new approved biologics are listed (in 2014), but they are not updated as of this date.

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Pharmacotherapy: Understanding Biotechnology Products

Taipei Medical University