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Skip to 0 minutes and 0 secondsMichel is 57 years old and he's undergoing a treatment for protocol for stage 3 colorectal carcinoma at an oncology centre on the East coast of America. His primary tumour and a blood sample were analysed using whole genome sequencing. The somatic genetic profile of his tumour and his drug metabolising genetic profile were used to design and individualised treatment protocol. Because Michel's treatment will include the use of a drug called Capecitabine, he is told that it is important to confirm that he does not have DPD deficiency.

Clinical scenario: personalised cancer treatment and variants of unknown significance

Please read the scenario and then watch the video. Then identify any terminology and concepts that you want to know more about. These will be addressed in our tutorials and suggested background reading.

In this scenario, genetic information can be used to stratify treatment, by modifying the dose of chemotherapy accordingly. Watch this patient story which introduces the use of pharmacogenetic tests to his management plan.

Scenario

Mikkel is 57 years old and he is undergoing treatment for a stage 3 colorectal carcinoma at an oncology centre on the east coast of America.

His primary tumour and a blood sample were analysed using whole genome sequencing.

The somatic genetic profile of his tumour, and his drug metabolising genetic profile were used to design an individualised treatment protocol.

Because Mikkel’s treatment will include the use of a drug called capecitabine he is told that it is important to confirm that he does not have DPD deficiency.

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This video is from the free online course:

Using Personalized Medicine and Pharmacogenetics

UEA (University of East Anglia)