Risk Factors & Prevention for radio contrast media, ACEI, and NSAID
Continuing from the previous step, Prof. Chen demonstrates the major medications which cause nephrotoxicity notable this time.
The first one is radio-contrast media. Since metformin has the side effect for lactic acidosis which may contribute to radio-contrast media induced nephrotoxicity, you will not dose it during the period when a patient is using radio-contrast media.
Also, the risk factors of radio-contrast media include diabetic nephropathy. Thus, patients with diabetes should use it very carefully.
The second one is ACE inhibitor, and the main risk factor is renal efferent arteriolar constriction.
The third one is NSAID. However, we can use some NSAID to prevent the nephrotoxicity, such as Sulindac.
Pharmacokinetics: Drug Dosing in Renal Disease
Pharmacokinetics: Drug Dosing in Renal Disease
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