Concerns: Aminoglycosides and Vancomycin in Renal Failure
In this step, Prof. Lee explains the 3 major concerns on using Aminoglycosides and Vancomycin in renal failure.
The first one is the toxicity. Both of them are known for adverse effects of nephrotoxicity and ototoxicity, which can be demonstrated by their structures.
The second one is where they are excreted. Both of them are extensively excreted by the kidneys.
Finally, they both represent the gold standard of therapeutic drug monitoring. Thus, we should pay attention to their serum concentration.
Besides, we can know their characteristics from the comparison table in this video, including their half-life, Volume of Distribution, and toxicity.
Ultimately, we can learn the intermittent infusion from this video. We should know how to calculate the dosing interval, and the meaning of peak and trough.
If you have any questions or thoughts, please share them below.
Please check the related file for week 3 course slides for your reference.
Pharmacokinetics: Drug Dosing in Renal Disease
Pharmacokinetics: Drug Dosing in Renal Disease
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