Example 4 : Carboplatin
Continuing, Prof. Lee explains how to calculate the oral maintenance dose of digoxin and how to estimate Carboplatin clearance.
First, we can assume that the bioavailability of digoxin is 0.7, and the half-life is 100 hr. Secondly, we can derive the daily dose by the formula. Finally, we should round it up to 150 ug/d, which can be one 0.1 mg +one 0.05 mg.
For example 4, we know that Carboplatin dosage (mg) would be the product of desired AUC and carboplatin clearance. However, please notice the differences in the formula between males and females.
Ultimately, Prof. Lee summarizes useful tools for the estimation of the dosing regimen in renal failure, including patient’s specific PK information, general formula, nomograph, specific formula, and TDM.
If you have any questions about this part, please leave them below.
Pharmacokinetics: Drug Dosing in Renal Disease
Pharmacokinetics: Drug Dosing in Renal Disease
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