Examples for PK properties & Dosing adjustment in Renal Failure
In this step, Prof. Lee gives the examples for predicted effects of hemodialysis on drug half-life and removal in the overdose setting first, including phenobarbital and salicylic acid.
Following that, for data interpretation, we should notice that the ultimate indicator for dialyzability is drug removal as a fraction of dose, and recurrent dialysis sessions may lead to significant drug removal.
Besides, we can see venous drug concentration rebound from the diagram. The red part means the period during hemodialysis, and the green part means interhemodialysis.
Finally, when facing dialysis patients, we had better dose at the end of dialysis to maintain the drug concentration. Also, we can supplement a dose following several sessions of dialysis.
Pharmacokinetics: Drug Dosing in Renal Disease
Pharmacokinetics: Drug Dosing in Renal Disease
Reach your personal and professional goals
Unlock access to hundreds of expert online courses and degrees from top universities and educators to gain accredited qualifications and professional CV-building certificates.
Join over 18 million learners to launch, switch or build upon your career, all at your own pace, across a wide range of topic areas.
