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Skip to 0 minutes and 10 secondsIAN LARSON: In this recording, you're going to learn about the pharmacokinetics of Gliclazide and how its elimination half-life influences how often Shirley needs to take her tablets. And you'll also learn about a newer type of tablet designed to be taken less frequently, making medicine taking easier. Yes, you have seen this graph before. You will remember, from my recording in week one, that a drug's elimination half-life is the time it takes for the drug concentration in the elimination phase to drop to half its concentration. And you'll also remember that this influences when you need to take your next dose of medicine.

Skip to 0 minutes and 50 secondsThe elimination half-life of Gliclazide is such that the Gliclazide concentration only drops below its minimum effective concentration at 12 hours. This means that you need to take Gliclazide tablets twice a day, usually once in the morning and once in the evening, generally with or around meals. If Shirley had difficulty swallowing tablets, taking one tablet per day would be easier for her than taking two. Some people also find it easier to remember to take one tablet per day than two. For these and other reasons, Gliclazide is available as a once-per-day tablet. This newer type of tablet, sometimes referred to a slow or modified released tablet, doesn't disintegrate and releases its drug over much longer time frames than conventional tablets.

Skip to 1 minute and 45 secondsAs shown on the graph, the Gliclazide concentration only falls below the minimum effective concentration after 24 hours, meaning that you only need to take one tablet per day.

Diabetes: pharmaceutics

Watch Ian explain the pharmacokinetics of gliclazide and its elimination half-life, and how these influence how often Shirley needs to take her tablets.


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This video is from the free online course:

The Science of Medicines

Monash University

Course highlights Get a taste of this course before you join:

  • Introduction: the healthcare team
    Introduction: the healthcare team
    video

    Watch Kirstie and Lyn describe health care teams and how doctors and pharmacists work together. Kirstie also provides a brief overview of the course.

  • Diabetes: patient introduction
    Diabetes: patient introduction
    video

    Watch Kirstie introduce Shirley Park, a mildly overweight patient with Type 2 diabetes. Unfortunately for Shirley, diet and exercise have not helped.

  •  Heart disease: patient introduction
    Heart disease: patient introduction
    video

    Watch Kirstie introduce Steve Park, an overweight 49-year-old with reflux and high blood pressure.

  • Pain patient introduction
    Pain patient introduction
    video

    Watch Kirstie introduces Ari, a gentleman with chronic back pain on multiple medications, including morphine tablets.

  • Smoking: patient introduction
    Smoking: patient introduction
    video

    Watch Kirstie introduce Tracey Wilson, a 28 years of age smoker who wants to quit.

  • Depression: patient introduction
    Depression: patient introduction
    video

    Watch Kirstie introduce Maria Tarantino, a 32 years of age mother of three, including a young baby who is suffering from a depressive disorder.

  • Depression pharmaceutics
    Depression pharmaceutics
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    Watch Ian combine medicine design and pharmaceutics to demonstrate how often fluoxetine needs to be taken.