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Skip to 0 minutes and 10 secondsIn my final recording for this course, I'm going to bring together both medicine design and pharmaceutics to understand Fluoxetine. Over the past few weeks you've learned about medicine designed for practical purposes, for example, taking a tablet once per day, instead of multiple times per day. You've also learned about elimination half lives and how they influence dosing frequency. The pharmaceutics of Fluoxetine is complicated and beyond the scope of this course, but you'll see that its dosing frequency is designed for reasons that you can understand. Before we go into the pharmaceutics of Fluoxetine, let's recap what you learned in week one.

Skip to 0 minutes and 50 secondsA drug's therapeutic window is the concentration range that we want the blood concentration of drug to remain in for as long as possible. The upper limit of the window is the minimum toxic concentration. If the blood concentration rises above this, Maria might experience side effects, such as headaches, nausea, and gut disorders. If the blood concentration of Fluoxetine falls below the lower limit-- the minimum effective concentration-- Maria's depression could return. Fluoxetine has a long half life of around four to six days. This contributes to its usual dosing frequency of once per day for the treatment of depressive disorders, such as suffered by Maria. This dosing interval maintains the blood concentration of Fluoxetine within the therapeutic window.

Skip to 1 minute and 38 secondsA more detailed investigation of the pharmaceutics of Fluoxetine is beyond the scope of this course. In week three, you learned that Shirley could take slow release tablets rather than traditional tablets, so that she didn't need to type them so often. But some people find it difficult to even swallow one tablet. For these people taking tablets regularly, even daily is difficult, and this can lead to them not taking their medicine when they need to. For these people scientists designed disposable tablets. These tablets are designed to disintegrate quickly, normally less than a minute in a small amount of water. This thing can be drunk just as a liquid medicine is.

Skip to 2 minutes and 21 secondsOver the pass six weeks you've learned about both drug pharmaceutics, elimination half lives, minimum effective, and minimum toxic concentrations, and medicine design. I hope you now better appreciate the science that lies behind the formulation and dosing requirements of medicines used to treat some of our biggest health issues. Next time you take a tablet, stop and picture in your mind what is about to happen

Depression pharmaceutics

Watch Ian combine medicine design and pharmaceutics to demonstrate how often fluoxetine needs to be taken.


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This video is from the free online course:

The Science of Medicines

Monash University

Course highlights Get a taste of this course before you join:

  • Introduction: the healthcare team
    Introduction: the healthcare team
    video

    Watch Kirstie and Lyn describe health care teams and how doctors and pharmacists work together. Kirstie also provides a brief overview of the course.

  • Diabetes: patient introduction
    Diabetes: patient introduction
    video

    Watch Kirstie introduce Shirley Park, a mildly overweight patient with Type 2 diabetes. Unfortunately for Shirley, diet and exercise have not helped.

  •  Heart disease: patient introduction
    Heart disease: patient introduction
    video

    Watch Kirstie introduce Steve Park, an overweight 49-year-old with reflux and high blood pressure.

  • Pain patient introduction
    Pain patient introduction
    video

    Watch Kirstie introduces Ari, a gentleman with chronic back pain on multiple medications, including morphine tablets.

  • Smoking: patient introduction
    Smoking: patient introduction
    video

    Watch Kirstie introduce Tracey Wilson, a 28 years of age smoker who wants to quit.

  • Depression: patient introduction
    Depression: patient introduction
    video

    Watch Kirstie introduce Maria Tarantino, a 32 years of age mother of three, including a young baby who is suffering from a depressive disorder.