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Skip to 0 minutes and 7 seconds Hi, and welcome to my lecture. My name is Jing-Wen Shih. In the following sections, we’ll talk about how to uncover potential drug targets and biomarkers by analyzing the expressions of numerous RNAs simultaneously, which is called RNA profiling.

Skip to 0 minutes and 28 seconds As mentioned in the previous sections, in human cells, DNA could be transcribed to generate messenger RNA (or called mRNA). mRNAs could be further translated to generate proteins. These gene expression processes are tightly controlled to help us grow, develop, and stay healthy.

Skip to 0 minutes and 53 seconds However, the mutation or aberrant expression of mRNA, which is usually caused by the DNA alteration, would probably lead to uncontrolled protein activity. This dysregulation of gene expression could be the cause of various clinical disorders.

Skip to 1 minute and 13 seconds In contrast to mRNAs, another group of RNA, the non-coding RNAs, are functional RNA molecules that are transcribed from DNA, but are not translated into proteins. Interestingly, many non-coding RNAs have the capacity to regulate gene expression at transcriptional and post-transcriptional levels.

Skip to 1 minute and 37 seconds Remarkably, the disruption of many non-coding RNAs have already been linked to various disease processes.

Skip to 1 minute and 47 seconds Thus, RNA expression is an important regulator and indicator of gene expression. Along these lines, genome-wide RNA expression profiling between patients and healthy controls could help us to understand pathogenesis and identify novel therapeutic targets or biomarkers. In the following sections, you’ll learn about different types of RNAs, their roles in disease pathogenesis and how we perform genome-wide RNA expression profiling to identify potential drug target candidates. We hope you will both learn from and enjoy this course. So let’s get going.

Introduction: RNA profiling and target identification

In this video, Prof. Shih will use a short animation to explain how RNA profiling happens.

RNAs are related to the gene targeting. When we know the process of RNA profiling, we might be able to find methods to identify it.


Prof. Jing-Wen Shih

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Introduction to Translational Research: Connecting Scientists and Medical Doctors

Taipei Medical University

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