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Possible Effects of FRB in AHR Ligand

Here I show you dietary tryptophan can prevent DSS-induced colitis via AHR. Tryptophan diet group in the wild-type (WT) mice effectively suppress DSS-induced inflammation in colon but not in AHR deficient mice. deficient knock out mice High content of tryptophan and tryptamine in fermented rice bran maybe contribute to express anti-colitis activity of fermented rice bran. Here is the summary of the final research. Fermented rice bran effectively prevented the DSS-induced colitis symptoms and severity. FRB reduced the serum proinflammatory cytokines and their mRNA than non-fermented rice bran.
FRB, fermented rice bran, increased the butyric acid, and as a short-chain fatty acid in the colon which might play important role in maintaining the epithelial layer integrity. Fermented rice bran containing high contains of tryptophan and tryptophan metabolites. So maybe these indole chemicals may be effective candidate for prevention of the UC which was found 6.5 times higher in fermented rice bran than non-fermented rice bran in case of the tryptophan.

Prof. Shirakawa suspected that the protective effects of FRB were via AhR(Aryl Hydrocarbon Receptor), so he further investigated the mechanism by using AhR deficient knock-out mice(KO). After DSS-administrated induced UC, the KO group showed to exaggerate UC symptoms, and reverse the treatment effects of FRB. The results showed strong evidence that the protective effects of FRB against UC symptoms were via modulation of AhR.

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Agriculture and Nutrition

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