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Possible Effects of FRB in AHR Ligand
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Prof. Shirakawa suspected that the protective effects of FRB were via AhR(Aryl Hydrocarbon Receptor), so he further investigated the mechanism by using AhR deficient knock-out mice(KO). After DSS-administrated induced UC, the KO group showed to exaggerate UC symptoms, and reverse the treatment effects of FRB. The results showed strong evidence that the protective effects of FRB against UC symptoms were via modulation of AhR.
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