What are the advantages and disadvantages of DDDs?
|Internationally recognised as assigned and published by WHO.||Unsuitable for paediatric settings as DDD defined as average dose in adults.|
|Once set by WHO a DDD is not often changed – this allows assessment of prescribing over time.||Can over or underestimate antibiotic use as do not account for alternative dosing regimes due to renal dysfunction, obesity etc.|
|Easy to produce information on antibiotic use expressed in DDD for ward, unit or hospital.||Bias against combination therapy – use of three narrow spectrum antibiotics rather than one broad spectrum antibiotic will result in three times as many DDD being used for the same infection.|
|Ability to compare antibiotic use in a standardised way between wards or hospitals.||May not reflect dose used for a particular infection.|
Antimicrobial Stewardship: Managing Antibiotic Resistance
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