Ron Konopka's Discovery of the PER Gene and Its Role in Circadian Rhythms
Professor Myung explains the role of time-delayed negative feedback in circadian clocks, with a focus on the PER gene. Mutations in PER influence the rhythmicity of circadian behavior, leading to long, short, or disrupted periods. Wild-type flies maintain close-to-24-hour rhythms, while PER mutants exhibit varied behaviors. Theoretical modeling resolved puzzles surrounding the gene’s location-dependent effects.
What might happen to humans if their circadian rhythms significantly deviate from 24 hours?
Circadian Clocks: Mastering Your Body’s Natural Rhythm
Circadian Clocks: Mastering Your Body’s Natural Rhythm
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