Time-delayed Negative Feedback
Professor Myung introduces Michael Rosbash’s Nobel-winning model of the circadian clock.
The model highlights time-delayed negative feedback in gene transcription and protein translation, proposing that delayed protein activity regulates gene expression, creating 24-hour oscillations. The process involves phosphorylation and feedback inhibition, forming a molecular circadian clock known as the transcriptional-translational feedback loop (TTFL). This framework elucidates the rhythmic biological mechanisms behind circadian timing.
Could human activities, such as shift work, disrupt molecular circadian clocks like TTFL?
Circadian Clocks: Mastering Your Body’s Natural Rhythm
Circadian Clocks: Mastering Your Body’s Natural Rhythm
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