Goldbeter's Model of PER Protein Degradation

Professor Myung discusses Albert Goldbeter’s theoretical model of circadian rhythms, which explains how mutations in the per gene affect periodicity.

Goldbeter proposed that the degradation rate of the PER protein is critical in determining rhythmic cycles. A higher degradation rate leads to longer periods, while a lower rate causes shorter periods. This mathematical model helps explain experimental findings and underscores the importance of degradation kinetics in circadian rhythm regulation.