TTFL and Time-Delayed Negative Feedback in Circadian Clocks
The professor explains that the circadian clock is governed by a time-delayed negative feedback mechanism (TTFL) involving genes like PER, TIM, BMAL1, and CRY. This genetic circuit, conserved across species, controls rhythmic behavior.
The length of the circadian period is determined by protein degradation rates, particularly of PER. The dynamics of protein accumulation and degradation drive the clock’s speed and rhythm, explaining various circadian behaviors in both Drosophila and mammals.
Circadian Clocks: Mastering Your Body’s Natural Rhythm
Circadian Clocks: Mastering Your Body’s Natural Rhythm
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