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Pharmacokinetic-Based Design and Modification of Dosage Regimens

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Read this paper “Pharmacokinetic-Based Design and Modification of Dosage Regimens” by Reza Mehvar, which was published in the American Journal of Pharmaceutical Education in 1998.

Reza had shown a early design of a clinical pharmacokinetics course module. He had revealed the general learning objectives.

  1. What is the goal when a dosage regimen is designed?

  2. What are the necessary data to design a dosage regimen for a patient, and how are the data obtained?

  3. How do alterations in volume of distribution (V), clearance (Cl), and elimination half life (t1/2) affect the plasma profiles of drugs after single and multiple dose administrations?

  4. Which kinetic parameter is important in determination of a loading dose?

  5. Which kinetic parameter affects the estimation of maintenance dose or rate of infusion?

When you are reading, please keep in mind these and try to answer one of them. You may write in the comments.

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Clinical Pharmacokinetics: Dosing and Monitoring

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