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How do clearance and volume impact the serum concentration?

How do clearance (CL) and volume (V) impact the serum concentration?

A change in clearance (CL) is a big issue. Prof. Brown uses a graph and a table to describe how it influences serum concentration (C) and AUC.

We can learn how to keep Cmax,ss and Cmin,ss from changing when clearance (CL) drops in half.

Besides, he places an emphasis on the effect of volume on Cmax and Cmin. Please pay attention to this. Changes in volume doesn’t affect AUC.

You might need to go back and review a couple of slides, make sure you understand the dynamics that take place.

When volume changes, how many parameters will change? And why? Please share your answer below.


Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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