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Protein binding: the impact of unbound drug

Protein binding: the impact of unbound drug

Prof. Brown begins with summaries of how parameters changing affects serum concentration(C) and AUC. We should understand the reason and the relationship instead of simply memorizing them.

He also clarifies the effect of the increase in fraction unbound (fu), and the relationship between Cu and fu.

What will change when fu doubles? And what is the pharmacologic effect? Please share your answer below.


Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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