Skip main navigation

Overview of this week


What can you expect to learn from this week? Professor Daniel Brown is going to explain the topic: The Challenges of Assessing Renal and Hepatic Clearance

Summary of Week 4:

1. Differences between drug elimination via filtration and biotransformation.
2. How renal function can be estimated based on creatinine clearance (CLCr) or GFR, for purposes of adjusting drug dosing.
3. How to correct (CLCr) or GFR to a standard body size.
4. The inherent sources of error associated with the Cockcroft-Gault equation that relate to body weight and muscle mass.
5. How the hepatic first-pass effect impacts drug bioavailability.
6. Hepatic extraction and the difference between High E and Low E drug clearance.
7. How hepatic clearance is affected by QH, CLint, and fu, and also how those factors affect Css, CU, and bioavailability.

We hope you enjoy.

This article is from the free online

Clinical Pharmacokinetics: Dosing and Monitoring

Created by
FutureLearn - Learning For Life

Reach your personal and professional goals

Unlock access to hundreds of expert online courses and degrees from top universities and educators to gain accredited qualifications and professional CV-building certificates.

Join over 18 million learners to launch, switch or build upon your career, all at your own pace, across a wide range of topic areas.

Start Learning now