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Hepatic Blood Flow & First-Pass Effect

Hepatic Blood Flow & First-Pass Effect

Prof. Brown introduces drugs that are metabolized by Cytochrome p450. Most of them are common drugs.

He also uses clear diagrams to demonstrate the concept of first-pass effect and bioavailability (F).

We can know the definition of hepatic extraction (EH) and clearance (CL).

What is the relationship between hepatic extraction (EH) and clearance (CL)? Please leave your answer below and explain why.


Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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