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Hepatic Metabolism Review : How will Css change if fu changes?

Hepatic Metabolism Review : How will Css change if fu changes?

Although we have learned the effect of fu increase before, this time we focus on how it impacts hepatic metabolism for a high E drug and a low E drug.

The hepatic metabolism review helps us consolidate knowledge. If you aren’t familiar with the concept, please review the previous video 4.7.

Besides, Prof. Brown gives a closer look at intrinsic clearance (CLint). Metabolic capacity depends on Vm and Km.

How will they affect CLint? Please leave your answer below and explain why.


Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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