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Michaelis- Menten Non-Linear metabolism & summary

Michaelis- Menten Non-Linear metabolism & summary

Prof. Brown demonstrates Michaelis-Menten non-linear metabolism with clear diagrams.

Like Phenytoin, it is easy to be metabolized in a capacity-limited (saturable) situation. It is common that clinical pharmacists monitor the serum concentration (C) of Phenytoin.

To sum up, the key to solving the puzzle of renal and hepatic dose adjustment is focusing on how the drug is eliminated. Renal filtration excretes drugs, and hepatic metabolism inactivates drugs.

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Prof. Daniel L. Brown

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Clinical Pharmacokinetics: Dosing and Monitoring

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