Cardiovascular diseases and fish oil

Weight-loss and dietary modification can improve metabolic syndrome. We already knew many benefit functions of omega-3 fatty acid. So is there any possible we can use omega-3 fatty acid to control metabolic syndrome ? Accroding to previous studies, omega-3 fatty acid can improved all components of disease. So, let’s start from the cardio vascular disorder. Many studies proved the cardiovascular protection by omega-3 fatty acid

which is, the mechanism is like this: reducing the risk of arrhythmias and the tendency for coronary restenosis; decreasing platelet aggregation and blood pressure, lowering plasma triglycerides; increasing HDLc and LDL particle size reducing improving vasodilatation From three large controlled trials with 32,000 participants that showed 19~45% reduction in cardiovascular events. And about Heart rate and Arrhythmias Administration of omega-3 fatty acid was associated with a reduction in heart rates in healthy people and those with coronary artery disease. Omega-3 fatty acid also useful in reducing the incidence of atrial fibrillation in patients undergoing coronary artery bypass surgery. The omega-3 fatty acid reduced the heart rate, prolongation of the PR interval and a reduction in the QT interval.

In the Ischemic stroke, the ongoing study provides satisfactory evidence regarding the role of omega-3 fatty acid in the secondary prevention of ischaemic stroke. Peripheral arterial disease omega-3 fatty acid in patients with peripheral arterial disease did not show significant benefits in terms of Ankle-brachial pressure index systolic blood pressure, plasma viscosity pain-free walking distance or maximal walking distance Another recent clinical trial showed marked improvement in endothelial function in subjects treated with omega-3 fatty acid Obesity. Obesity contributes to diabetes mellitus, hypertension and cardiovascular disorders especially apple shaped obesity. Weight loss.

Weight loss is a very important issues for the metabolic syndrome so, dietary and lifestyle modifications reduces the risk of developing these diseases Incorporation of omega-3 fatty acid in a weight-loss diet reduces in fasting insulin, glucose and triglycerides. And also it improves improves oxidative stress. About the Dyslipidaemia Major effect of omega-3 fatty acid is to reduce plasma triglyceride concentration The ratio of triglycerides to HDLc (the atherogenic index) is lower in people treated in omega-3 fatty acid. which is mean can decrease the atherosclerosis. The LDL particle size was observed to be higher and the quantity of small dense LDL particles was observed to be less.

As we know, larger LDL particle sizes are associated with less risk of atherosclerosis A reduction in this highly atherogenic lipoprotein fraction of plasma is another important beneficial effect of treatment with omega-3 fatty acid. About Diabetes The major benefit of omega-3 fatty acid in Type 2 diabetes mellitus is improving atherogenic lipid profile decrease insulin resistance In The Diabetes Autoimmunity Study in the Young (DAISY) omega-3 fatty acid showed that lower development of pancreatic islet-cell autoimmunity risk of developing type 1 diabetes About the Hypertension omega-3 fatty acid reduce both systolic and diastolic blood pressure. People consuming omega-3 fatty acid on a regular basis have been found to be less likely to develop hypertension.

Most studies investigating the effect of fish oils in reducing blood pressure used higher doses which is around 3.7 g/day. and a reduction in systolic blood pressure and diastolic blood pressure Beneficial effects of omega-3 fatty acid on blood pressure reduction tended to be greater in older subjects ( the subject’s age is over45 years) and hypertensive patients.

Although fish oil has lots of benefits but most of that is for cardiovascular diseases like lowering serum triglyceride and blood cholesterol Lowering blood pressure and Rheumatoid arthritis (fish oil) prevention Cardiovascular disease prevention But still has unclear scientific evidence like cardiac arrhythmias (abnormal heart rhythms) cancer prevention, Infant eye / brain development, colon cancer prevention So we need more studies in the future to clearfy these parts Thank you for your listening. Any question will be welcome.