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Effects of Renal Failure on ADME

Effects of Renal Failure on ADME

This week, we will learn dosing regimen and TDM in renal failure.

Prof. Lee clarifies the effects of renal failure on ADME in this step.

To begin with, we should know ADME, including absorption, distribution, metabolism, and excretion.

For absorption, renal failure generally decreases it. For distribution, renal failure decreases plasma protein binding due to competition for accumulated fatty acids and other metabolic products.

For metabolism, renal failure does not usually affect drug metabolism until the very end-stage. Prof. Lee will also explain the effects of renal failure on clearance, half-life, and pharmacodynamics as well.

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Pharmacokinetics: Drug Dosing in Renal Disease

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