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Dosing Adjustment: Assumptions and Dosing Regimen

Dosing Adjustment: Assumptions and Dosing Regimen

In this step, Prof. Lee explains how to adjust the dosing regimen in renal failure.

If the IV infusion rate is constant, we can assume the same therapeutic concentration (Css), and use the relationship between infusion rate (R) and total clearance (Cl) to get what we want.

If the drug is administrated orally, we should consider the bioavailability (F), and use the final formula in this step to calculate its dosing regimen.

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Pharmacokinetics: Drug Dosing in Renal Disease

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