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Derivation and Application of K Ratio

Derivation and Application of K Ratio

In this step, Prof. Lee explains how to use the K ratio and the formula.

To begin with, renal excretion of drug is proportional to creatinine clearance. Therefore, we can get the formulas shown in the first slide.

Following that, we can divide both sides by Kn to express the k ratio.

If we assume that Knr/ Kn is a constant, the formula will be the same form as y = mx +b.

As a result, we can draw the formulas in a diagram, and evaluate the need for dosing adjustment.

What kinds of patients’ dosing need(s) to be adjusted in the diagram shown on the last slide?

Please share your answers and thoughts below.

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Pharmacokinetics: Drug Dosing in Renal Disease

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