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General approach to K ratio : Example 1

General approach to K ratio : Example

In this step, Prof. Lee explains the general approach to K ratio and how to estimate initial dose in uremia.

In the first slide, those drugs in category L have the small or the minimum knr to Kn ratio, indicating that they are very extensively excreted by the kidneys.

Following that, we can learn that initial dose in uremia is closely related to fraction of drug excreted unchanged in the urine (fe), and kidney function as a fraction of normal (KF).

Finally, we need to understand the relationship between K, Kr. and Knr. Therefore, we can know the accurate K.

Do you know the value of fe in the example? Please leave your answer below.

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Pharmacokinetics: Drug Dosing in Renal Disease

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