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Calculate IV Loading Dose of Digoxin : Example 3

Calculate Loading Dose of Digoxin : Example 3

In this step, Prof. Lee illustrates how to estimate the IV digoxin loading dose.

We know that we need the volume of distribution (V) by his hint.

Therefore, we should calculate the IBW and BSA first, then get Clcr by C-G equation to know V.

Finally, the product of V and the desired therapeutic concentration is the IV loading dose. We should notice that digoxin needs to be administered as a slow IV push.

Please try the exercise on your own to check your understanding, and share your answer below.

MT is a 60 yo, 80 kg, 5’10” male with atrial fibrillation, for which his doctor prescribed digoxin. In addition, he showed moderate, stabilized renal impairment, serum creatinine 1.4 mg/dl. The desired therapeutic concentration for this patient is 1.3 ng/ml. • Calculate an IV digoxin loading dose to provide the therapeutic concentration.

In the next step, we will discuss how to calculate the oral maintenance dose to maintain the therapeutic concentration of digoxin.

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Pharmacokinetics: Drug Dosing in Renal Disease

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