Skip main navigation

New offer! Get 30% off your first two months of Unlimited. Subscribe for just £35.99 £24.99. New subscribers only. T&Cs apply.

Find out more

Example 4 : Carboplatin

Example 3 : Oral Digoxin Maintenance dose & Example 4 : Carboplatin

Continuing, Prof. Lee explains how to calculate the oral maintenance dose of digoxin and how to estimate Carboplatin clearance.

First, we can assume that the bioavailability of digoxin is 0.7, and the half-life is 100 hr. Secondly, we can derive the daily dose by the formula. Finally, we should round it up to 150 ug/d, which can be one 0.1 mg +one 0.05 mg.

For example 4, we know that Carboplatin dosage (mg) would be the product of desired AUC and carboplatin clearance. However, please notice the differences in the formula between males and females.

Ultimately, Prof. Lee summarizes useful tools for the estimation of the dosing regimen in renal failure, including patient’s specific PK information, general formula, nomograph, specific formula, and TDM.

If you have any questions about this part, please leave them below.

This article is from the free online

Pharmacokinetics: Drug Dosing in Renal Disease

Created by
FutureLearn - Learning For Life

Reach your personal and professional goals

Unlock access to hundreds of expert online courses and degrees from top universities and educators to gain accredited qualifications and professional CV-building certificates.

Join over 18 million learners to launch, switch or build upon your career, all at your own pace, across a wide range of topic areas.

Start Learning now