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TDM: Purpose & Examples : Tobramycin & Vancomycin

TDM: Purpose & Examples : Tobramycin & Vancomycin

In this step, Prof. Lee illustrates the purpose of Therapeutic Drug Monitoring (TDM), and gives examples for different drugs.

To begin with, we know that the side effect could be unbearable for the patient. Thus, the purpose of therapeutic drug monitoring is to adjust the plasma concentration to avoid the toxicity and to optimize or maximize the efficacy.

Secondly, we can learn to distinguish the peak and the trough concentration from the table in the TDM example for Tobramycin.

Besides, there are some important hints. When we use TDM on Aminoglycosides, do not make clinical decisions on numbers alone.

Finally, we should notice that the target trough of Vancomycin is between 10 and 15 ug/ml, depending on the patient’s situation.

Have you completed any TDM before? What was the target trough of Vancomycin ? If possible, you can share which country you’re in as well.

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Pharmacokinetics: Drug Dosing in Renal Disease

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