Skip main navigation

Concerns: Aminoglycosides and Vancomycin in Renal Failure

Concerns: Aminoglycosides and Vancomycin in Renal Failure

In this step, Prof. Lee explains the 3 major concerns on using Aminoglycosides and Vancomycin in renal failure.

The first one is the toxicity. Both of them are known for adverse effects of nephrotoxicity and ototoxicity, which can be demonstrated by their structures.

The second one is where they are excreted. Both of them are extensively excreted by the kidneys.

Finally, they both represent the gold standard of therapeutic drug monitoring. Thus, we should pay attention to their serum concentration.

Besides, we can know their characteristics from the comparison table in this video, including their half-life, Volume of Distribution, and toxicity.

Ultimately, we can learn the intermittent infusion from this video. We should know how to calculate the dosing interval, and the meaning of peak and trough.

If you have any questions or thoughts, please share them below.

This article is from the free online

Pharmacokinetics: Drug Dosing in Renal Disease

Created by
FutureLearn - Learning For Life

Reach your personal and professional goals

Unlock access to hundreds of expert online courses and degrees from top universities and educators to gain accredited qualifications and professional CV-building certificates.

Join over 18 million learners to launch, switch or build upon your career, all at your own pace, across a wide range of topic areas.

Start Learning now