A case for Gentamycin : 2
Continuing from the previous step, Prof. Lee illustrates the other questions this time.
First, we can calculate volume of distribution (V) since we already have elimination constant rate (k), infusion time (t), peak concentration (C peak), and loading dose (K0).
Secondly, we can derive the clearance from the equation : CL= k * V.
Following that, knowing peak and trough concentration, we will be able to calculate the suitable dosing interval, and find out the appropriate infusion rate.
Finally, due to the individualized dosing regimen, we do not have to alter our dosage recommendation for obese patients.
If you have any questions or thoughts, please share them below.
Pharmacokinetics: Drug Dosing in Renal Disease
Pharmacokinetics: Drug Dosing in Renal Disease
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