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General questions 1


Prof. Lee explains the first general question 1 : Drug A is primarily excreted unchanged in the urine, dosage adjustment is usually necessary when the patient’s creatinine clearance is_______mL/min.

When is dosage adjustment usually necessary? This is very easy to guess.

When a patient’s creatinine clearance is less than 50 milliliter per minute, which is about only 50% of normal renal function, we would reduce the dose by 50% in general.

Let’s move on to general question2.

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Pharmacokinetics: Drug Dosing in Renal Disease

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