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General questions 10: Metformin

General questions 10: Metformin

Continuing from the previous step, Prof. Lee explains the final general question this time.

This question is significant. Why is metformin warned for use in patients with a creatinine clearance less than 60?

The reason is that it is excreted to greater than 80% exquisite unchanged by the kidneys.

Besides, from the additional information he provides, we can know that Taiwan FDA recommend if GFR is between 30 and 45, we should reduce metformin dosage; if GFR is less than 30, then metformin is simply contraindicated.

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Pharmacokinetics: Drug Dosing in Renal Disease

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