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Mechanics of Dialyzabilty & Pharmacokinetic Properties

Mechanics of Dialyzabilty & Pharmacokinetic Properties

In this step, Prof. Lee introduces the mechanics of dialyability and its pharmacokinetic properties.

To begin with, mechanics of dialyzabiltiy include blood flow, dialysate flow, permeability of dialyzer membrane, configuration of dialysate flow against blood flow, and dialysis interval.

Following that, we can learn that there are some pharmacokinetic properties.

We can see clearance and half-life as independent parameters. However, if we take them together into consideration, with high clearance and short half-life, the majority of the drug is cleared primarily by the host system, leading to minor dialysis effect.

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Pharmacokinetics: Drug Dosing in Renal Disease

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