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Examples for PK properties & Dosing adjustment in Renal Failure

Examples for PK properties & Dosing adjustment in Renal Failure

In this step, Prof. Lee gives the examples for predicted effects of hemodialysis on drug half-life and removal in the overdose setting first, including phenobarbital and salicylic acid.

Following that, for data interpretation, we should notice that the ultimate indicator for dialyzability is drug removal as a fraction of dose, and recurrent dialysis sessions may lead to significant drug removal.

Besides, we can see venous drug concentration rebound from the diagram. The red part means the period during hemodialysis, and the green part means interhemodialysis.

Finally, when facing dialysis patients, we had better dose at the end of dialysis to maintain the drug concentration. Also, we can supplement a dose following several sessions of dialysis.

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Pharmacokinetics: Drug Dosing in Renal Disease

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