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Risk Factors & Prevention for AMG, Cyclosporine, and Amphotericin B

Risk Factors & Prevention for AMG, Cyclosporine, and Amphotericin B

In this step, Prof. Chen introduces three major medications, which cause nephrotoxicity notable.

The first one is aminoglycoside. The risk factors include concurrent nephrotoxic drugs. Thus, we can do well hydration, limit total dose, or monitor PK to prevent this nephrotoxicity.

The second one is Cyclosporine, an important immunosuppressant used for transplant patients. It is difficult to differentiate cyclosporine-induced nephrotoxicity and allograft rejection. Therefore, we need to monitor cyclosporine level and check the signs and symptoms clinically.

The final one is Amphotericin B, and the risk factors include baseline renal function, cumulative dose, diuretics, and rapid infusion.

If you have any questions about this part, please leave them below.

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Pharmacokinetics: Drug Dosing in Renal Disease

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