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Specific therapy & Complications of ARF

Specific therapy & Complications of ARF

In this step, Prof. Chen demonstrates the specific therapy for intrinsic ARF and post-renal azotemia, then explains complications of ARF.

To begin with, for intrinsic ARF, we can use gluco-corticosteroids to treat those with allergic interstitial nephritis, and use clonidine, prazosin or CCB to treat those with malignant hypertensive nephrosclerosis.

For post-renal azotemia, we can remove calculus or other obstruction. If the patient has salt-wasting syndrome, we can use 0.45% saline to improve the situation.

Finally, there are plenty of complications of ARF, including metabolic, cardiovascular, neuromuscular, hematologic, gastrointestinal syndrome, and infection.

Infection is very important which makes ARF worse. Therefore, antibiotics selection is also important when dealing with ARF.

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Pharmacokinetics: Drug Dosing in Renal Disease

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