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Fluid and Electrolytes imbalance : Hyperphosphatemia & hypocalcemia

Fluid and Electrolytes imbalance : Hyperphosphatemia and hypocalcemia

In this step, Prof. Chen explains hyperphosphatemia, hypocalcemia, hypermagnesemia, and calcium and phosphorus balance.

To begin with, hyperphosphatemia is from reduced renal excretion and excessive cellular release, and hypocalcemia is from an abnormal PTH level.

For calcium and phosphorus balance, we need to keep the product of calcium concentration and the phosphate level less than 55 milligrams per deciliter.

Besides, there are other polymer binders, including Sevelamer HCL and Sevelamer carbonate. However, they may cause some ADRs, such as fecal impaction and intestinal obstruction.

Following that, there is another new phosphate binder, called Lanthanum, which dissociates into a trivalent cation with similar binding. Lanthanum will reduce the bioavailability of ciprofloxacin and levothyroxine.

Have you ever used Lanthanum in clinical practice? Please share your experience before.

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Pharmacokinetics: Drug Dosing in Renal Disease

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