Course: Circadian Clocks: Mastering Your Body’s Natural Rhythm

Clocks in the Wild: Entrainment to Natural Light. This paper attempts to provide a mathematical explanation of chronotype through a related concept in entrainment theory called the phase of entrainment. …

A marker for the end of adolescence This paper reports age-dependent and gender-dependent differences in chronotype. This study examines how sleep patterns vary with age and gender. Analyzing data from …

Encoding seasonal information in a two-oscillator model of the multi-oscillator circadian clock Cellular circadian clocks synchronize their rhythms, but in the SCN, this synchronization may be modulated by specific light …

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms The Other Link This is the first study to demonstrate that circadian clocks reside within single cells. …

Please take some time to read the research: A model for circadian oscillations in the Drosophila period protein (PER). This simulation paper demonstrates a theoretical basis for the circadian clock …

Clock mutants of Drosophila melanogaster This is a classic paper by Konopka and Benzer that marked the beginning of research into the molecular basis of the circadian clock. The abstract …

On temperature independence in the clock system controlling emergence time in Drosophila. This study demonstrates the temperature compensation of the circadian eclosion rhythm in fruit flies. This is one of …

The birth of chronobiology: a botanical observation Circadian biology began with the observations made by de Marian in 1729. This brief article discusses the circumstances and significance of this discovery. …

Circadian entrainment aligns internal rhythms to a 24-hour day using light, notably blue light. Variations in light intensity and geographical factors affect chronotype distribution. Social jet lag results from misalignment …

Chronotype, measured as mid-sleep time on free days, reflects individual circadian rhythms. Early chronotypes (“larks”) wake early, while late chronotypes (“owls”) stay up late. Chronotypes shift later in youth and …

Professor Myung explores the SCN’s role as the mammalian master clock. Cells in the SCN exhibit spontaneous synchronization while maintaining distinct phase gaps, enabling effective circadian organization. Unlike simple systems, …

Circadian rhythms, reflected in parameters like body temperature, are distinct from sleep-wake cycles. Humans’ intrinsic circadian period exceeds 24 hours and persists in darkness. Sleep-wake timing, influenced by social obligations, …

Professor Myung explains how synchronization occurs in circadian rhythms within the SCN (suprachiasmatic nucleus) using principles observed by Christiaan Huygens in pendulum clocks. The phenomenon involves weak coupling, as seen …

Professor Myung highlights the role of the suprachiasmatic nucleus (SCN) as the master circadian clock. Without the SCN, organisms lose 24-hour rhythmicity in activities. SCN neurons generate action potentials, with …

Professor Myung explains how circadian clocks synchronize in organisms. While flies’ clocks directly respond to light, mammals rely on the suprachiasmatic nucleus (SCN) to process light signals from the retina …