Course: Clinical Pharmacokinetics: Dosing and Monitoring

Hello, Learners! Welcome to our pharmacokinetics series. I am Prof. Shawn Chen, the main educator of this course. The international group of instructors for this course are: Daniel Brown, Pharm …

Continuing from the previous video, Prof. Brown specifies how a loading dose relates to the volume of distribution (V). He shows the relationship between elimination and accumulation during a drug …

Prof. Brown puts great emphasis on how to design a multiple dosing regimen based on Cav,ss in this part. We can learn how to convert a dosing rate to a …

In this video, we start with “How can we determine the safest and most effective dose of the drug for a specific patient?” Prof. Brown illustrates the outline and the …

This week, Professor Daniel Brown is going to explain the dosing basics, and how to determine the right amount of drug for a patient. Summary of Week 2: Compare and …

Please read the abstract of the paper published by Prof. Brown. This report describes student perceptions of the Fish Tank Model of first-order elimination as a learning aid in a …

Prof. Brown explains the reason why protein binding (fu) changes only matters for highly protein bound drugs and how it influences clearance (CL). Another factor that affects clearance (CL) is …

Prof. Brown illustrates the definition of Mean Residence Time (MRT) in this video. MRT is a measure of drug exposure over time. He also explains that under some conditions, protein …

This video is about the relationship between half-life (t 1/2), serum concentration (C), and Eliminate Rate Constant (k). After learning how Volume (V) and Clearance (CL) influence k, this time …

Why does an increase in V cause k to decrease? Why does an increase in CL cause k to increase? In this section, we can learn how clearance (CL) and …

Prof. Daniel Brown clarifies the definition of various parameters. He also illustrates the meaning of Volume of Distribution (V), so we can understand how it relates to a body. Besides …

In this video, Prof. Daniel Brown first introduces the assumptions and ground rules for this course. He illustrates the importance of focusing on practical patient care rather than a laboratory …

What can you expect to learn from this week? Professor Daniel Brown will explain the topic: The Fish Tank – A Simplified Model of First-Order Elimination. Summary of Week 1: …

Vancomycin is a glycopeptide antibiotic. It is one of the most widely used antibiotics in the United States for the treatment of serious gram-positive infections. Please read the article. The …

How to calculate the Cmax and Cmin on Vancomycin IV bolus? How to monitor trough level of Vancomycin at steady state? How to revise Vancomycin dosing and when? (We are …