Course: Clinical Pharmacokinetics: Dosing and Monitoring

In this video, we can first learn TDM on Vancomycin. Trough level can be used as a surrogate marker of AUC. Besides, with the introduction of Aminoglycoside, we can know …

The teacher, Marcie Wu, is the clinical pharmacist in WangFang Hospital, and the adjunct Instructor at Taipei Medical University, She gives an introduction to Vancomycin, and its pharmacokinetics and pharmacodynamics. …

What can you expect to learn from this week? Pharmacist Marcie Wu is going to explain the topic: Clinical application – vancomycin and gentamycin case practice Summary of Week 6: …

Prof. Brown lists the advantages of Extended-interval aminoglycoside dosing, and its precautions. He uses the Hartford Nomogram to illustrate how to use a suitable dose. We found the prevalence of …

We can morph two dosing equations to calculate Cpeak,ss for an intermittent infusion dosing regimen. Prof. Brown illustrates two steps on Aminoglycoside serum level analysis. How long will it take …

Prof.Brown reveals the potential advantages of vancomycin continuous infusion, including no trough level monitoring. He also mentions that dosing by a continuous infusion is very common in Europe, but not …

Prof. Brown uses an example to describe how to adjust Vancomycin dosing based on AUC (24hr). We can understand AUC therapeutic targets for Vancomycin, including maximizing efficacy and minimizing nephrotoxicity. …

Prof. Brown summarizes the pharmacokinetic differences between Aminoglycosides and Vancomycin. We can learn traditional Vancomycin dosing from a dosing chart from Wanfang Hospital. We consider the dose by the weight, …

How can we optimize efficacy and minimize toxicity when dosing aminoglycosides and vancomycin? Based on pharmacokinetic and pharmacodynamic considerations, we can understand the importance of the killing type of an …

What can you expect to learn from this week? Professor Daniel Brown is going to explain the topic: What Pharmacists Need to Know about Dosing Aminoglycosides and Vancomycin Summary of …

Prof. Brown demonstrates Michaelis-Menten non-linear metabolism with clear diagrams. Like Phenytoin, it is easy to be metabolized in a capacity-limited (saturable) situation. It is common that clinical pharmacists monitor the …

Although we have learned the effect of fu increase before, this time we focus on how it impacts hepatic metabolism for a high E drug and a low E drug. …

Prof. Brown introduces drugs that are metabolized by Cytochrome p450. Most of them are common drugs. He also uses clear diagrams to demonstrate the concept of first-pass effect and bioavailability …

Prof. Brown clarifies the clearance of high E drugs and low E drugs. We can learn the factors affect low E drugs, such as fu and intrinsic clearance. On the …

After a brain exercise for the timing to adjust the dose, Prof. Brown gives an example for Januvia (Sitagliptin) adjustment. When the value of CLcr using ideal body weight (IBW) …