Tobramycin Dosing Regimen : Example 2
In this video, Prof. Lee demonstrates the steps to estimate the dosing regimen of Tobramycin. To begin with, we can see that in the first diagram, the y-axis is the …
Course: Pharmacokinetics: Drug Dosing in Renal Disease
General approach to K ratio : Example 1
In this step, Prof. Lee explains the general approach to K ratio and how to estimate initial dose in uremia. In the first slide, those drugs in category L have …
Derivation and Application of K Ratio
In this step, Prof. Lee explains how to use the K ratio and the formula. To begin with, renal excretion of drug is proportional to creatinine clearance. Therefore, we can …
Oral Administration : Dosing Regimen Strategy
In this step, Prof. Lee introduces several equations based on assumptions that some parameters are unchanged. First, if we assume that the therapeutic concentration (Css) and the bioavailability (F) are …
Dosing Adjustment: Assumptions and Dosing Regimen
In this step, Prof. Lee explains how to adjust the dosing regimen in renal failure. If the IV infusion rate is constant, we can assume the same therapeutic concentration (Css), …
Effects of Renal Failure on ADME
This week, we will learn dosing regimen and TDM in renal failure. Prof. Lee clarifies the effects of renal failure on ADME in this step. To begin with, we should …
Urinary Excretion Rate Method: Example
There are mainly two ways to determinate renal clearance, including Excretion Rate Method, and Urinary Recovery Method. In this step, we can learn how to use Excretion Rate Method to …
Renal Drug Recovery & Excretion Pathways : Mechanism
In this step, Prof. Lee clarifies Renal Drug Recovery and renal excretion pathways. To begin with, high urinary recovery (>80%) indicates that the drug is primarily excreted by the kidneys, …
Clinical Diagnosis of Stages of Chronic Kidney Disease
In this step, Prof. Lee illustrates the different stages of Chronic Kidney Disease based on GFR in mL/min/1.73m2 . In clinical situation, we will consider Cystatin-C as well. When estimated …
Other Methods for creatinine clearance estimation
Prof. Lee introduces three other methods for creatinine clearance in this step. Continuing from the previous step, he says that Cockroft-Gault tends to overestimate the creatinine clearance for those who …
GFR Estimation : MDRD Formula
In this step, Prof. Lee illustrates the correction factor, examples, and the advantages for MDRD formula (Levey Equation). First, the correction factor depends on the races and the gender. Secondly, …
Examples: Cockroft-Gault Calculation
Continuing from the previous step, Prof. Lee gives two examples to illustrate Cockroft-Gault Calculation this time. The first case is a male patient. We need to know how to calculate …
GFR Estimation : Cockroft-Gault Equation
Continuing from the previous step, Prof. Lee illustrates Cockroft-Gault Equation this time. To begin with, we have to know that direct measurement of GFR by endogenous creatinine is most accurate …
Renal Function by Serum Markers
In this step, Prof. Lee explains three serum markers, including serum creatinine (Ccr), blood urea nitrogen (BUN), and serum cystatin-C. When we use serum creatinine as a marker, we should …
Renal Function Tests: GFR, Renal Plasma Flow, and serum maker
In this step, Prof. Lee gives a brief introduction to different kinds of renal function tests, including GFR, renal plasma flow, and serum marker. There are several methods helping us …
